Angela Lignelli, MD
Neuroradiology
Diagnostic Radiology
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Overview
Dr. Angela Lignelli is an associate professor of radiology at Columbia University Irving Medical Center (CUIMC) and associate chair of patient experience for the Department of Radiology. She is board certified in diagnostic radiology and subspecialty certified in neuroradiology.
Dr. Lignelli’s clinical focus includes brain tumor imaging in both adults and children. She specializes in advanced imaging techniques including MR perfusion, MR spectroscopy and functional MRI. Her primary research interests involve correlating anatomic and non-anatomic brain imaging of brain tumors with neuoropathologic markers and clinical outcomes. Her secondary research interest involves pediatric neuroimaging in metabolic disorders.
Dr. Lignelli has spent the duration of her career in radiology at CUIMC/NewYork-Presbyterian (NYP), where she completed her radiology residency and neuroradiology fellowship before becoming a member of the faculty. She is a member of the Vagelos College of Physician and Surgeon's Academy of Clinical Excellence (ACE).
In addition to her clinical and research expertise, Dr. Lignelli is a committed educator, both to medical students and residents of the NYP/CUIMC community. She served as program director for the Diagnostic Radiology Residency for several years.
Academic Appointments
- Associate Professor of Radiology at CUMC
Administrative Titles
- Chief, Division of Neuroradiology
- Associate Chair of Patient Experience
Hospital Affiliations
- NewYork-Presbyterian Westchester
- NewYork-Presbyterian / Columbia University Irving Medical Center
- NewYork-Presbyterian Allen Hospital
Languages
- Italian
Gender
- Female
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Credentials & Experience
Education & Training
- University of Medicine and Dentistry of New Jersey
- Internship: 1994 Yale-New Haven Hospital
- Residency: Yale-New Haven Hospital
- Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
- Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center
Board Certifications
- Neuroradiology
- Diagnostic Radiology
America's Top Doctor
NY Top Doctor
Research
Selected Publications
- Chow DS, Horenstein CI, Canoll P, Lignelli A, Hillman EM, Filippi CG, Grinband J. Glioblastoma Induces Vascular Dysregulation in Nonenhancing Peritumoral Regions in Humans. AJR Am J Roentgenol. 2016 Mar 23:1-9.
- Garg A, Patel P, Lignelli A, Baron E, Kazim M. Coincidental Optic Nerve Meningioma and Thyroid Eye Disease. Ophthal Plast Reconstr Surg. 2014 May 14.
- Dagi Glass LR, Canoll P, Lignelli A, Ligon AH, Kazim M. Optic Nerve Glioma: Case Series With Review of Clinical Radiologic , Molecular , and Histopathologic Characteristics. Ophthal Plast Reconstr Surg. 2014 Apr 23.
- Zacharia BE, Gulati AP, Bruce JN, Carminucci AS, Wardlaw SL, Siegelin M, Remotti H, Lignelli A, Fine RL. High response rates and prolonged survival in patients with corticotroph pituitary tumors and refractory Cushing disease from capecitabine and temozolomide (CAPTEM): a case series. Neurosurgery. 2014 Apr;74(4):E447-55;
- Chow DS, Qi J, Guo X, Miloushev VZ, Iwamoto FM, Bruce JN, Lassman AB, Schwartz LH, Lignelli A, Zhao B, Filippi CG. Semiautomated Volumetric Measurement on Postcontrast MR Imaging for Analysis of Recurrent and Residual Disease in Glioblastoma Multiforme. AJNR Am J Neuroradiol. 2014 Mar;35(3):498-503
- Chow DS, Hauptman JH, Wong TT, Gonzalez NR, Martin NA, Lignelli A, Itagaki MW. Changes in stroke research productivity: A Global Perspective. Surg Neurol Int. 2012;3:27.
- Lignelli A, Khandji AG. Review of imaging techniques in the diagnosis and management of brain metastases. Neurosurgery Clinics of North America. 2011 Jan;22(1):15-25,v.
- Masdeu JC, Ajtai B, Leung DK, Lignelli-Dipple A, and Ichise M. Normal structural and functional neuroanatomy for SPECT and PET Imaging, Chapter 5, pp. 54-70, in Functional Cerebral SPECT and PET Imaging, Fourth Edition: Van Heertum RL, Tikofsky RS, Ichise M (Eds.). Functional Cerebral SPECT and PET Imaging, Fourth Edition. Philadelphia, Lippincott Williams & Wilkens, 2010.
- Komotar RJ, Connolly ES, Lignelli A, Mack WJ, Mocco, J, Harbaugh RE. Clinicoradiologic review: bilateral ethmoidal arteriovenous fistulas. Neurosurgery. 2007 Jan:60(1):131-5; discussion 135-6
- D'Ambrosio AL, Williams SC, Lignelli A, Salchow DJ, Spicer G, Libien J, Chin SS, Liebsch NJ, Kazim M, Bruce JN, Connolly ES Jr. Clinicopathologic review: giant cell reparative granuloma of the orbit. Neurosurgery. 2005 Oct;57(4):773-8.
- Imielinska C, Liu X, Rosiene J, Sughrue ME, Komotar RJ, Mocco J, Ransom ER, Lignelli A, Zacharia BE, Connolly ES, D'Ambrosio AL. Toward objective quantification of perfusion-weighted computed tomography in subarachnoid hemorrhage: quantification of symmetry and automated delineation of vascular territories. Academic radiology. 2005 Jul;12(7):874-87.
- Millar W, Lignelli A, Hirano, M. MRI of five patients with mitochondrial neurogastrointestinal encephalomyopathy). American Journal of Roentgenology. 2004 Jun;182(6):1537-41.
- Fawwaz RA., Wang TST., Das S, Lignelli A, DeRosa C, Van Heertum RL: Radiolabeled Streptavidin: A Potential Breast Tumor Imaging Agent. Annals of Nuclear Medicine 12:137,1999.
- Malaspina D, Storer S, Gorman, JM, Lignelli A, Furman V, Berman A, Van Heertum RL: SPECT Brain Imaging: Study of Visual Fixation in Schizophrenia. Biological Psychiatry 14: 89-93,1999.
- Mayer SA, Lignelli A, Fink ME, Kessler DB, Swarup R, Van Heertum RL: Perilesional Blood Flow and Edema Formation in Acute Intracerebral Hemorrhage: A SPECT Study. Stroke 29: 1791-1798, 1998.
- Malaspina D, Perrera GM, Lignelli A, Marshall RS, Esser PD, Storer S, Furman V, Wray AD, Coleman E, Gorman JM, Van Heertum RL: SPECT imaging of Odor Discrimination in Schizophrenia. Psychiatry Research 82:53- 61, 1998.
- Plutchok J, Lignelli A, Van Heertum: Correlative Abdominal Nuclear Medicine Imaging - Part II: "Something New". Contemporary Diagnostic Radiology 20:7-12, 1997.
- Yaron I, Lignelli A, Oluwole SF, Hardy MA: Clinical Implications of the Relative Resistance of Umbilical Cord Blood CD34+ Stem Cells to UVB Irradiation. Surgical Forum XLVII: 439-442, 1996.
- Trepeta S,Chan S, Lignelli A: Imaging in Mesial temporal Sclerosis - emedicine - updated August 2009
- D'Ambrosio AL, Williams SC, Lignelli A, Salchow DJ, Spicer G, Libien J, Chin SS, Liebsch NJ, Kazim M, Bruce JN, Connolly ES Jr. Clinicopathologic review:giant cell reparative granuloma of the orbit. Neurosurgery. 2005 Oct;57(4):773-8.
- Imielinska C, Liu X, Rosiene J, Sughrue ME, Komotar RJ, Mocco J, Ransom ER, Lignelli A, Zacharia BE, Connolly ES, D'Ambrosio AL. Toward objective quantification of perfusion -weighted computed tomography in subarachnoid hemorrhage: quantification of symmetry and automated delineation of vascular territories. Academic radiology. 2005 Jul;12(7):874-87.
- W. Millar, A. Lignelli, M. Hirano. MRI of five patients with mitochondrial neurogastrointestinal encephalomyopathy). American Journal of Roentgenology. 2004 Jun;182(6):1537-41.
- Fawwaz RA., Wang TST., Das S, Lignelli A, DeRosa C, Van Heertum RL: Radiolabeled Streptavidin: A Potential Breast Tumor Imaging Agent. Annals of Nuclear Medicine 12:137,1999.
- Malaspina D, Storer S, Gorman, JM, Lignelli A, Furman V, Berman A, Van Heertum RL: SPECT Brain Imaging: Study of Visual Fixation in Schizophrenia. Biological Psychiatry 14: 89-93,1999.
- Mayer SA, Lignelli A, Fink ME, Kessler DB, Swarup R, Van Heertum RL: Perilesional Blood Flow and Edema Formation in Acute Intracerebral Hemorrhage: A SPECT Study. Stroke 29: 1791-1798, 1998.
- Malaspina D, Perrera GM, Lignelli A, Marshall RS, Esser PD, Storer S, Furman V, Wray AD, Coleman E, Gorman JM, Van Heertum RL: SPECT imaging of Odor Discrimination in Schizophrenia. Psychiatry Research 82:53-61, 1998.
- Plutchok JJ, Lignelli A, Van Heertum: Correlative Abdominal Nuclear Medicine Imaging - Part II: "Something New". Contemporary Diagnostic Radiology 20:7-12, 1997.
- Yaron I, Lignelli A, Oluwole SF, Hardy MA: Clinical Implications of the Relative Resistance of Umbilical Cord Blood CD34+ Stem Cells to UVB Irradiation. Surgical Forum XLVII: 439-442, 1996.