Junhao (Hao) Wen, PhD

Junhao (Hao) Wen, PhD, is a computational neuroscientist with expertise in medical image computing, artificial intelligence/machine learning, multi-omics, and multi-organ bioinformatics. He is the director of imaging genetics research at Columbia's Center for Innovation in Imaging Biomarkers and Integrated Diagnostics (CIMBID) and an affiliated member at the New York Genome Center. He is also guest faculty at the Center for AI and Data Science for Integrated Diagnostics (AI2D) at the University of Pennsylvania and the founding co-chair of the Brain Imaging Genetics workgroup of the International Society for Advancing Alzheimer's Disease Research and Treatment, the largest international Alzheimer's research community.

Dr. Wen’s research focuses on developing and applying artificial intelligence/machine learning techniques to analyze multi-organ and multi-omics biomedical data in the context of human aging and disease, with a particular emphasis on clinical and computational neuroscience to advance precision medicine. His work aims to leverage AI’s capabilities to uncover insights beyond human perception, encompassing several key areas. First, he uses artificial intelligence/machine learning to explore the genetic underpinnings of disease-related neuroanatomical variations (imaging genetics), enabling personalized diagnostic and prognostic approaches. Second, his research adopts a holistic multi-organ and multi-omics framework, recognizing the interconnected nature of organ systems to unravel the complexities of brain structure and function. Furthermore, he leads and contributes to initiatives aimed at consolidating and harmonizing large-scale biomedical datasets, such as the MULTI consortium, which integrates multi-organ and multi-omics data to advance holistic human aging and disease modeling. A central objective of Dr. Wen’s research is to integrate AI-driven decision-support systems into clinical practice, identifying genetic, proteomic, and imaging biomarkers that will inform future therapeutic strategies.

Dr. Wen has a diverse academic and research background. He obtained his BS and MS degrees from Beihang University in Beijing, China and his PhD in computer science at Sorbonne University in Paris, France. He also worked as a visiting scholar at the University of College London, London, UK, during his PhD. Dr. Wen completed his postdoctoral training at the University of Pennsylvania. Before joining Columbia Radiology, he was a tenure-track assistant professor at the University of Southern California.

Visit Dr. Wen's lab.