Roman Fleysher, PhD

  • Associate Professor of Radiology (Physics) at CUIMC
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Overview

Dr. Roman Fleysher, PhD, is an associate professor of radiology (physics) at Columbia University Irving Medical Center (CUIMC). His research interests include measurement principle of MRI, image quality optimization, image analysis and their applications to the study of the human brain in conjunction with cognitive, clinical, demographic, and other measurements.

Dr. Fleysher received his PhD in experimental high energy elementary particle astrophysics from New York University, after which he followed his childhood dream of “developing medical equipment” and continued his education in much lower energies, those of radio waves in MRI, at the Center For Neural Science at NYU. There, he developed improved image reconstruction and distortion correction algorithms and implemented first isotropic sub-millimeter resolution imaging for functional MRI to study columnar architecture of the human visual cortex. 

Over the course of his career, Dr Fleysher developed methods for efficient data acquisition, its analysis and interpretation in relaxometry, B1 mapping, diffusion and perfusion, functional MRI, hyperpolarized imaging and spectroscopy. He developed novel image registration algorithms, quality and MRI-derived imaging metrics with applications in aging, mild traumatic brain injury, epilepsy in humans and rodents. He continues to work in these and other areas to enhance detection of abnormalities on MRI, beyond what was previously thought possible. 

Academic Appointments

  • Associate Professor of Radiology (Physics) at CUIMC

Gender

  • Male

Credentials & Experience

Education & Training

  • MS, Tomsk State University (Russia)
  • PhD, New York University

Research

Selected Publications

Individuals with sickle cell disease and sickle cell trait demonstrate no increase in mortality or critical illness from COVID-19 - A fifteen hospital observational study in the Bronx, New York. Wouter S Hoogenboom, Roman Fleysher, Selvin Soby, Parsa Mirhaji, William B Mitchell, Kerry A Morrone, Deepa Manwani, Tim Q Duong. Haematologica, 106 (2021), 3014.

Registration quality filtering improves robustness of voxel-wise analyses to the choice of brain template. Nelson Gil, Michael L. Lipton, Roman Fleysher. NeuroImage 227 (2021), 117657.

MRI-defined White Matter Microstructural Alteration Associated with Soccer Heading Is More Extensive in Women than Men. T. G. Rubin, E. Catenaccio, R Fleysher, L. E. Hunter, N. Lubin, W. F. Stewart, M. Kim, R. B. Lipton, Michael L. Lipton. Radiology 289 (2018), 478-486.

White matter microstructural abnormalities in blast-exposed combat veterans: accounting for potential pre-injury factors using consanguineous controls. A. C. McClelland, R. Fleysher, W. Mu, N, Kim, M. L. Lipton. Neuroradiology 60 (2018), 1019-1033.

Subject Based Registration for Individualized Analysis of Diffusion Tensor MRI. A. K. Suri, R. Fleysher, M.L. Lipton. PLoS One, 10 (2015), e0142288.

Blood tracer kinetics in the arterial tree. E. Kellner, P. Gall, M. Günther, M. Reisert, I. Mader, R. Fleysher, V.G. Kiselev. PLoS ONE, 9 (2014), e109230.

TROMBONE: T1-Relaxation-Oblivious Mapping of Transmit Radio-Frequency Field (B1) for MRI at High Magnetic Fields. R. Fleysher, L. Fleysher, M. Inglese, D. Sodickson. Magnetic Resonance in Medicine, 66 (2011), 483-491.

Extended para-hydrogenation monitored by NMR spectroscopy. J.A. Tang, F. Gruppi, R. Fleysher, D.K. Sodickson, J.W. Canary, A. Jerschow. Chemical Communications, 47 (2011), 958-960.

On the Voxel Size and Magnetic Field Strength Dependence of Spectral Resolution in MR Spectroscopy. R. Fleysher, L. Fleysher, S. Liu, O. Gonen. Magnetic Resonance Imaging, 27 (2009), 222-232.

TRITONE: a Radio-Frequency Field (B1) Insensitive T1 Estimator for MRI at High Magnetic Fields. R. Fleysher, L. Fleysher, S. Liu, O. Gonen. Magnetic Resonance Imaging, 26 (2008), 781-789.

The optimal MR acquisition strategy for exponential decay constants estimation. R. Fleysher, L. Fleysher, O. Gonen. Magnetic Resonance Imaging 26 (2008), 433-435.

Optimizing the precision-per-unit-time of quantitative MR metrics: Examples for T1, T2, and DTI. L. Fleysher, R. Fleysher, S. Lui, W. Zaaraoui and O. Gonen, Magnetic Resonance in Medicine 57 (2007), 380-387.

Tests of Statistical Significance and Background Estimation in Gamma Ray Air Shower Experiments. R. Fleysher, L. Fleysher, P. Nemethy, A.I. Mincer, and T.J. Haines,  Astrophysical Journal 603 (2004), 355-362.

Publications with the Milagro Collaboration

Observation and Spectral Measurements of the Crab Nebula with Milagro. A.A. Abdo et al., Astrophysical Journal, 750 (2012), 63.

Evidence for TeV Gamma-Ray Emission from a Region of the Galactic Plane. R. Atkins et. al., Physical Review Letters 95 (2005), 251103.

Search for Very High Energy Gamma Rays from WIMP annihilations near the Sun with the Milagro Detector. R. Atkins et. al., Physical Review D 70 (2004), 083516.

TeV Observations of Markarian 501 with the Milagrito Water Cherenkov Detector. R. Atkins et al., Astrophysical Journal Letters 525 (1999), L25-L28.

Selected Presentations at International Conferences

High resolution fMRI using a 3D multi-shot EPI sequence. L. Fleysher, R. Fleysher, D. J. Heeger, S. Inati. In Proceedings of 13th ISMRM (2005, Miami Beach), 2685.